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KMID : 0861020030180030131
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Korea Journal of Herbology
2003 Volume.18 No. 3 p.131 ~ p.141
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Experimental Studies on T-cell Subsets of the Ginseng Radix Rubra
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徐榮培/Seo, Young-Bae
安圭相/李永喆/An, Kyu-Sang/Lee, Young-Cheol
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Abstract
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Objective : This study was carried out for the purpose of knowing the effect from T-cell activation of the C57BLh mouse by the extraction from a EGRR.
Methods : CD80, CD86, CD28, CTW-4 is the most imporbnt costimulatory molecules. CD80 and CD86 molecules are expressed on activated antigen-presenting cells(APCs) and bind to their ligands CD28 and CTLA-4 on T cells.
Natural CD4 CD25+ T cells may be candidates as a major regulatory T-cell subset. Indeed, CD4 CDE+ T cells were shown to control autoreactive T cells. CD44 mediates leukocyte activation and CD69 acts as a costimulatory molecule for T cell activation and proliferation. So we investigated the effects of EGRR on cell surface antigens(CD25, CD28, CD44, CD69, CD80) expressed by T cells following activation.
Results : 1. In order to know the effect of the cytotoxicity from extraction of EGRR, we had to examine the safe density of that on lung fibroblast cells of the mouse(mLFCs). EGRR did not show cytotoxicity against mLFCs.
2. In the prolifeous effect of thymus T cells, water extracts of GRR played an important role on the
proliferating thymus T cells compared with control group.
3. EGRR up-regulates CD44´CD69´CD25´, CD4´CD25´, CD8´CIY25´. CD3´CD80´ expression but not CD3´CDB´ by anti -CD3- stimulated T cells.
Conclusions : -4bove results indicates that EGRR play an important role in the activation of autoreactive T cells by up-regulating cell surface molecule(CD80, CD25, CD44). Therefore further deep stucfies shoud be accomplished about its mechanisms.
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